Os9 Gene Summary [Mouse]
Predicted to enable protease binding activity. Predicted to be involved in several processes, including negative regulation of retrograde protein transport, ER to cytosol; protein retention in ER lumen; and proteolysis involved in protein catabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum lumen. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human OS9 (OS9 endoplasmic reticulum lectin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Os9 |
| Official Name | amplified in osteosarcoma [Source:MGI Symbol;Acc:MGI:1924301] |
| Ensembl ID | ENSMUSG00000040462 |
| Bio databases IDs | |
| Aliases | amplified in osteosarcoma |
| Synonyms | 4632413K17RIK, amplified in osteosarcoma, AU022351, ERLEC2, LOC102547508, OS9 endoplasmic reticulum lectin, OS9, endoplasmic reticulum lectin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Os9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protease binding
- Glucosidase II beta subunit-like protein
- protein binding
- mannose 6-phosphate receptor homology domain
Pathways
Biological processes and signaling networks where the Os9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- insomnia
- androgenic alopecia
- ulcerative colitis
- multiple sclerosis
role in cell
- expression in
- endoplasmic reticulum-associated degradation in
- downregulation in
- decay in
- retention in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell surface
- perinuclear region
- cellular membrane
- vesicles
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Os9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting
- endoplasmic reticulum unfolded protein response
- retrograde protein transport, ER to cytosol
- response to endoplasmic reticulum stress
- protein retention in ER lumen
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- Hrd1p ubiquitin ligase complex
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- protease binding
- carbohydrate binding