Ripply2

Involved in somite rostral/caudal axis specification. Acts upstream of or within several processes, including Notch signaling pathway; determination of left/right symmetry; and post-anal tail morphogenesis. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in embryo mesoderm; paraxial mesenchyme; and tail bud. Used to study spondylocostal dysostosis. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 6. Orthologous to human RIPPLY2 (ripply transcriptional repressor 2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ripply2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Ripply2 gene, providing context for its role in the cell.