Notch1 Gene Summary [Mouse]
Enables several functions, including Notch binding activity; transcription coactivator activity; and transcription regulator activator activity. Involved in several processes, including circulatory system development; negative regulation of cell differentiation; and regulation of signal transduction. Acts upstream of or within several processes, including circulatory system development; epithelial cell differentiation; and regulation of epithelial cell differentiation. Located in several cellular components, including adherens junction; apical plasma membrane; and cell surface. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia/lymphoma; aortic valve disease 1; and congenital heart disease. Orthologous to human NOTCH1 (notch receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Notch1 |
| Official Name | notch 1 [Source:MGI Symbol;Acc:MGI:97363] |
| Ensembl ID | ENSMUSG00000026923 |
| Bio databases IDs | |
| Aliases | notch 1 |
| Synonyms | 9930111A19Rik, AOS5, AOVD1, hN1, lin-12, Mis6, N1, NOTCH, notch receptor 1, TAN1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Notch1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EP domain
- transcription regulator
- JMTM_Notch_APP
- Cdc-phosphodegrons
- RAM domain
- Ankyrin repeats (many copies)
- calcium-binding EGF-like domain
- transcription co-activator
- enzyme inhibitor activity
- transcription activation domain
- chromatin binding
- glutamine-rich domain
- identical protein binding
- Ankyrin repeat
- transformation domain
- EGF_CA
- cytoplasmic domain
- intracellular domain
- transmembrane receptor
- extracellular domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- CDC domain
- opa repeat
- nucleic acid binding
- ectodomain
- negative regulatory domain
- nuclear localization sequence
- Human growth factor-like EGF
- LNR domain
- Ankyrin repeats (3 copies)
- enzyme binding
- protein binding
- sequence-specific DNA binding
- EGF-like domain
- DNA binding
- PEST domain
- NOTCH protein
- ankyrin binding domain
- Lin-12/Notch repeat
- double-stranded DNA binding
- transmembrane domain
- ICN1 domain
- heterodimerization domain
- OPA domain
- cytosolic tail domain
- EGF repeat
- notch binding
Pathways
Biological processes and signaling networks where the Notch1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Chronic Myeloid Leukemia Signaling
- Epithelial Adherens Junction Signaling
- Estrogen Receptor Signaling
- Molecular Mechanisms of Cancer
- Notch Signaling
- Osteoarthritis Pathway
- Pancreatic Adenocarcinoma Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- soft tissue sarcoma cancer
- cancer
- atherosclerosis
- transitional cell bladder cancer
- colorectal cancer
- urothelial bladder carcinoma
- precursor B-cell acute lymphoblastic leukemia
- breast adenocarcinoma
- Adams-Oliver syndrome type 5
role in cell
- activation in
- expression in
- migration
- cell death
- production in
- cell viability
- number
- phosphorylation in
- colony formation
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- glutaminergic synapse
- ruffle
- intracellular compartment
- cytoskeleton
- Cytoplasm
- cell surface
- Extracellular Space
- cell periphery
- intracellular space
- apical compartment
- perinuclear region
- membrane surface
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- membrane compartment
- cytosol
- endoplasmic reticulum membrane
- apical membrane
- synaptic membrane
- lateral plasma membrane
- Golgi membrane
- endosomal membrane
- nucleoplasm
- nuclear speckles
- acrosome
- dendritic spines
- synapse
- cytoplasmic vesicles
- junctional complexes
- chromatin
- perikaryon
- dendrites
- cell-cell adherens junctions
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Notch1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endoderm development
- inhibition of neuroepithelial cell differentiation
- regulation of epithelial cell proliferation involved in prostate gland development
- axon guidance
- positive regulation of Ras protein signal transduction
- secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
- branching morphogenesis of a tube
- negative regulation of extracellular matrix constituent secretion
- negative regulation of cell migration involved in sprouting angiogenesis
- cardiac right atrium morphogenesis
- cellular response to follicle-stimulating hormone stimulus
- endocardial cushion morphogenesis
- negative regulation of collagen biosynthetic process
- immune response
- epithelial cell proliferation
- cardiac chamber formation
- negative regulation of transcription, DNA-dependent
- in utero embryonic development
- cardiac ventricle morphogenesis
- negative regulation of cell-substrate adhesion
- positive regulation of transcription, DNA-dependent
- cardiac atrium morphogenesis
- humoral immune response
- heart looping
- negative regulation of biomineral tissue development
- positive regulation of epithelial cell proliferation
- negative regulation of cell adhesion molecule production
- aortic valve morphogenesis
- atrioventricular valve morphogenesis
- coronary sinus valve morphogenesis
- pulmonary valve morphogenesis
- compartment pattern specification
- ventricular trabecula myocardium morphogenesis
- pericardium morphogenesis
- cardiac left ventricle morphogenesis
- luteolysis
- epidermal cell fate specification
- negative regulation of catalytic activity
- cardiac right ventricle formation
- negative regulation of myoblast differentiation
- protein import into nucleus
- retinal cone cell differentiation
- negative regulation of epithelial cell proliferation
- epithelial to mesenchymal transition
- hair follicle morphogenesis
- organ regeneration
- tube formation
- Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- regulation of stem cell proliferation
- outflow tract morphogenesis
- cell migration involved in endocardial cushion formation
- positive regulation of transcription from RNA polymerase II promoter
- endocardium development
- negative regulation of osteoblast differentiation
- heart development
- negative regulation of anoikis
- cardiac vascular smooth muscle cell development
- liver development
- left/right axis specification
- negative regulation of glial cell proliferation
- neuroendocrine cell differentiation
- oligodendrocyte differentiation
- astrocyte differentiation
- regulation of cell adhesion involved in heart morphogenesis
- endocardium morphogenesis
- atrioventricular node development
- negative regulation of calcium ion-dependent exocytosis
- cardiac septum morphogenesis
- cardiac muscle cell myoblast differentiation
- ventricular septum morphogenesis
- determination of left/right symmetry
- coronary vein morphogenesis
- negative regulation of BMP signaling pathway
- positive regulation of BMP signaling pathway
- positive regulation of smooth muscle cell differentiation
- response to lipopolysaccharide
- calcium ion-dependent exocytosis
- cellular response to vascular endothelial growth factor stimulus
- neural tube development
- positive regulation of cardiac muscle cell proliferation
- negative regulation of auditory receptor cell differentiation
- cell differentiation in spinal cord
- response to muramyl dipeptide
- sprouting angiogenesis
- transcription from RNA polymerase II promoter
- positive regulation of astrocyte differentiation
- negative regulation of cell proliferation involved in heart valve morphogenesis
- negative regulation of photoreceptor cell differentiation
- positive regulation of endothelial cell differentiation
- auditory receptor cell fate commitment
- arterial endothelial cell differentiation
- negative regulation of oligodendrocyte differentiation
- venous endothelial cell differentiation
- forebrain development
- inflammatory response to antigenic stimulus
- skeletal muscle cell differentiation
- negative regulation of cardiac muscle hypertrophy
- glomerular mesangial cell development
- cellular response to hypoxia
- epithelial cell fate commitment
- cardiac muscle tissue morphogenesis
- embryonic hindlimb morphogenesis
- positive regulation of keratinocyte differentiation
- cilium morphogenesis
- mesenchymal cell development
- cardiac epithelial to mesenchymal transition
- positive regulation of neuroblast proliferation
- endocardial cell differentiation
- positive regulation of transcription of Notch receptor target
- cardiac muscle cell proliferation
- positive regulation of JAK-STAT cascade
- keratinocyte differentiation
- negative regulation of gene expression
- Notch signaling pathway
- positive regulation of gene expression
- distal tubule development
- negative regulation of neurogenesis
- T-helper 17 type immune response
- positive regulation of cell migration
- negative regulation of cell-cell adhesion mediated by cadherin
- prostate gland epithelium morphogenesis
- coronary artery morphogenesis
- mitral valve formation
- epithelial to mesenchymal transition involved in endocardial cushion formation
- positive regulation of Notch signaling pathway
- neuronal stem cell maintenance
- negative regulation of transcription from RNA polymerase II promoter
- collecting duct development
- somatic stem cell division
- negative regulation of stem cell differentiation
- negative regulation of endothelial cell chemotaxis
- negative regulation of pro-B cell differentiation
- negative regulation of myotube differentiation
- positive regulation of viral genome replication
- lung development
- foregut morphogenesis
- heart trabecula morphogenesis
- protein catabolic process
- spermatogenesis
- regulation of transcription, DNA-dependent
- growth involved in heart morphogenesis
- vasculogenesis involved in coronary vascular morphogenesis
- tissue regeneration
- regulation of transcription from RNA polymerase II promoter
- negative regulation of canonical Wnt receptor signaling pathway
- regulation of somitogenesis
- homeostasis of number of cells within a tissue
- positive regulation of ERK1 and ERK2 cascade
- negative regulation of ossification
- cellular response to tumor cell
Cellular Component
Where in the cell the gene product is active
- MAML1-RBP-Jkappa- ICN1 complex
- Golgi membrane
- receptor complex
- extracellular region
- plasma membrane
- cell surface
- nucleoplasm
- endoplasmic reticulum membrane
- nucleus
- adherens junction
- acrosomal vesicle
- cytosol
- endosome membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- identical protein binding
- transmembrane signaling receptor activity
- protein binding
- transcription coactivator activity
- enzyme inhibitor activity
- calcium ion binding
- core promoter proximal region sequence-specific DNA binding
- Notch binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- enzyme binding