Epha4 Gene Summary [Mouse]
Enables GPI-linked ephrin receptor activity; identical protein binding activity; and transmembrane-ephrin receptor activity. Involved in several processes, including axon development; cellular response to amyloid-beta; and regulation of neuron projection development. Acts upstream of or within several processes, including adult walking behavior; nephric duct morphogenesis; and nervous system development. Located in several cellular components, including axon; dendrite; and early endosome membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Orthologous to human EPHA4 (EPH receptor A4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Epha4 |
| Official Name | Eph receptor A4 [Source:MGI Symbol;Acc:MGI:98277] |
| Ensembl ID | ENSMUSG00000026235 |
| Bio databases IDs | |
| Aliases | Eph receptor A4 |
| Synonyms | 2900005C20Rik, AI385584, Cek8, EK8, EPH receptor A4, HEK8, rb, RGD1560587, SEK, Sek1, TYRO1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Epha4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase
- SAM domain
- ephrin receptor binding
- Fibronectin type 3 domain
- protein-tyrosine kinase
- Protein kinase domain
- identical protein binding
- GPI-linked ephrin receptor
- Sterile alpha motif
- transmembrane-ephrin receptor
- cytoplasmic domain
- SAM domain (Sterile alpha motif)
- intracellular domain
- membrane-proximal domain
- Tyrosine kinase, catalytic domain
- Dbl homology domain
- Ligand Binding Domain of Ephrin Receptors
- Protein kinase (unclassified specificity)
- protein kinase binding
- MAPK binding site
- Protein tyrosine and serine/threonine kinase
- SAM (Sterile alpha motif )
- protein domain specific binding
- protein binding
- beta-amyloid binding
- PH-domain binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
- transmembrane receptor protein tyrosine kinase
- FN3
- Ephrin receptor ligand binding domain
Pathways
Biological processes and signaling networks where the Epha4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pancreatic cancer
- acute myeloid leukemia
- prostate cancer
- cataract
- gait disturbance
- non-insulin-dependent diabetes mellitus
- papillary thyroid carcinoma
- papillary thyroid cancer
- experimental autoimmune encephalomyelitis
- glioma
role in cell
- expression in
- apoptosis
- activation in
- density
- translation in
- phosphorylation in
- production in
- proliferation
- adhesion
- induction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- axon component
- Cytoplasm
- cell surface
- cellular membrane
- cell cortex
- presynaptic membrane
- postsynaptic membrane
- mitochondrial outer membrane
- endosomal membrane
- dendritic spines
- neuromuscular junctions
- growth cone
- dendrite initial segments
- synapse
- cellular protrusions
- filopodia
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Epha4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- negative regulation of long-term synaptic potentiation
- adherens junction organization
- motor axon guidance
- positive regulation of protein tyrosine kinase activity
- corticospinal tract morphogenesis
- positive regulation of cell proliferation
- protein autophosphorylation
- axon guidance
- negative regulation of cellular response to hypoxia
- cell adhesion
- positive regulation of cell adhesion
- regulation of astrocyte differentiation
- protein phosphorylation
- glial cell migration
- adult walking behavior
- negative regulation of axon regeneration
- negative regulation of epithelial to mesenchymal transition
- positive regulation of Rho guanyl-nucleotide exchange factor activity
- negative regulation of neuron projection development
- regulation of axonogenesis
- negative regulation of translation
- positive regulation of dendrite morphogenesis
- regulation of dendritic spine morphogenesis
- cochlea development
- negative regulation of cell adhesion
- fasciculation of sensory neuron axon
- fasciculation of motor neuron axon
- negative regulation of ERK1 and ERK2 cascade
- nephric duct morphogenesis
- regulation of GTPase activity
- ephrin receptor signaling pathway
- protein stabilization
- negative regulation of cell migration
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- mitochondrial outer membrane
- perikaryon
- plasma membrane
- axon terminus
- cell surface
- early endosome membrane
- dendrite
- adherens junction
- cytoplasm
- axonal growth cone
- dendritic shaft
- dendritic spine
- filopodium
- neuromuscular junction
- axon
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- ephrin receptor binding
- protein kinase activity
- GPI-linked ephrin receptor activity
- PH domain binding
- DH domain binding
- beta-amyloid binding
- transmembrane-ephrin receptor activity
- ATP binding
- protein tyrosine kinase activity
- protein binding
- kinase activity