Osr1 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including embryonic limb morphogenesis; kidney development; and regulation of transcription by RNA polymerase II. Acts upstream of or within gonad development; intermediate mesoderm development; and metanephros development. Predicted to be located in cell cortex and cytosol. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; genitourinary system; and limb. Orthologous to human OSR1 (odd-skipped related transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Osr1 |
| Official Name | odd-skipped related transcription factor 1 [Source:MGI Symbol;Acc:MGI:1344424] |
| Ensembl ID | ENSMUSG00000048387 |
| Bio databases IDs | |
| Aliases | odd-skipped related transcription factor 1 |
| Synonyms | ODD, Odd1, odd-skipped related transcription factor 1, Osr |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Osr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- kinase domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- Zinc-finger double domain
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck squamous cell carcinoma
- invasive breast cancer
- edema
- rectal adenocarcinoma
- colorectal carcinomagenesis
- rectum cancer
- head and neck squamous cell cancer
- breast carcinoma
- thyroid carcinoma
- epithelial thyroid cancer
role in cell
- expression in
- apoptosis
- proliferation
- phosphorylation in
- development
- migration
- differentiation
- chemotaxis
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cell cortex
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Osr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryo development
- ureter urothelium development
- metanephric cap mesenchymal cell proliferation involved in metanephros development
- embryonic digit morphogenesis
- mesangial cell development
- renal vesicle progenitor cell differentiation
- pattern specification involved in metanephros development
- mesonephros development
- positive regulation of epithelial cell proliferation
- embryonic forelimb morphogenesis
- embryonic hindlimb morphogenesis
- positive regulation of bone mineralization
- embryonic skeletal joint morphogenesis
- negative regulation of nephron tubule epithelial cell differentiation
- mesonephric duct morphogenesis
- negative regulation of epithelial cell differentiation
- embryonic skeletal joint development
- positive regulation of gene expression
- metanephric mesenchyme morphogenesis
- metanephric interstitial cell development
- palate development
- chondrocyte differentiation
- middle ear morphogenesis
- odontogenesis
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- heart development
- metanephric mesenchymal cell differentiation
- stem cell differentiation
- specification of posterior mesonephric tubule identity
- specification of anterior mesonephric tubule identity
- intermediate mesoderm development
- posterior mesonephric tubule development
- negative regulation of sodium ion transmembrane transporter activity
- metanephric smooth muscle tissue development
- metanephric epithelium development
- embryonic skeletal limb joint morphogenesis
- regulation of transcription from RNA polymerase II promoter
- pronephros development
- metanephric mesenchyme development
- urogenital system development
- gonad development
- cellular response to retinoic acid
- metanephric nephron tubule development
- ureteric bud development
- negative regulation of apoptotic process
- cell proliferation involved in kidney development
- metanephric glomerulus vasculature development
- cell differentiation
- positive regulation of gastrulation
- sodium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- cell cortex
- cytosol
- chromatin
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity