Map3k7 Gene Summary [Mouse]
Enables MAP kinase kinase activity; MAP kinase kinase kinase kinase activity; and receptor tyrosine kinase binding activity. Involved in several processes, including anoikis; negative regulation of necroptotic process; and positive regulation of canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including intracellular signaling cassette; regulation of signal transduction; and tube morphogenesis. Located in postsynaptic density. Is expressed in several structures, including brain; gut; male reproductive gland or organ; metanephros; and respiratory system. Used to study Wolff-Parkinson-White syndrome. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia; frontometaphyseal dysplasia 2; and prostate cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map3k7 |
| Official Name | mitogen-activated protein kinase kinase kinase 7 [Source:MGI Symbol;Acc:MGI:1346877] |
| Ensembl ID | ENSMUSG00000028284 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase 7 |
| Synonyms | B430101B05, CSCF, FMD2, Map3k7 predicted, MEKK7, mitogen-activated protein kinase kinase kinase 7, TAK1, TGF1a, Tgf beta Activated Kinase1, Tgf β Activated Kinase1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Map3k7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- punt binding
- protein kinase
- ATP-binding domain
- ATP binding
- transcription factor binding
- enzyme
- Protein kinase domain
- identical protein binding
- receptor tyrosine kinase binding
- MAP kinase kinase kinase kinase
- MAP kinase
- Tyrosine kinase, catalytic domain
- ubiquitin protein ligase binding
- Protein kinase (unclassified specificity)
- protein kinase binding
- autoinhibitory protein domain
- Protein tyrosine and serine/threonine kinase
- ubiquitin binding
- protein binding
- MAP kinase kinase kinase
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- MAP kinase kinase
- kinase domain
- serine/threonine phosphorylation motif
- Protein Kinases, catalytic domain
Pathways
Biological processes and signaling networks where the Map3k7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- BMP signaling pathway
- Cardiomyocyte Differentiation via BMP Receptors
- CD27 Signaling in Lymphocytes
- CD40 Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glucocorticoid Receptor Signaling
- GNRH Signaling
- HGF Signaling
- IL-17A Signaling in Airway Cells
- IL-17A Signaling in Fibroblasts
- LPS-stimulated MAPK Signaling
- Mouse Embryonic Stem Cell Pluripotency
- NF-κB Signaling
- p38 MAPK Signaling
- PPAR Signaling
- PPARα/RXRα Activation
- RANK Signaling in Osteoclasts
- Role of NFAT in Cardiac Hypertrophy
- TGF-β Signaling
- Toll-like Receptor Signaling
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight loss
- cancer
- liver neoplasia
- epithelial neoplasia
- epithelial cancer
- neoplasia
- liver cancer
- cardiospondylocarpofacial syndrome
- acute myeloid leukemia
- hypoplasia
role in cell
- phosphorylation in
- activation in
- molecular cleavage in
- cell viability
- expression in
- induction in
- degradation in
- quantity
- apoptosis
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- ribosome
- Nucleus
- Plasma Membrane
- cytosol
- endoplasmic reticulum membrane
- endosomal membrane
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Map3k7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JUN kinase activity
- I-kappaB phosphorylation
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- Fc-epsilon receptor signaling pathway
- transforming growth factor beta receptor signaling pathway
- positive regulation of cell cycle
- JNK cascade
- stimulatory C-type lectin receptor signaling pathway
- cytoplasmic pattern recognition receptor signaling pathway
- MAPK cascade
- inflammatory response
- chromatin remodeling
- MyD88-dependent toll-like receptor signaling pathway
- immune response
- positive regulation of cell size
- cellular response to tumor necrosis factor
- cellular response to hypoxia
- T cell receptor signaling pathway
- stress-activated MAPK cascade
- positive regulation of interleukin-2 production
- positive regulation of macroautophagy
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
- p38MAPK cascade
- toll-like receptor 4 signaling pathway
- anoikis
- I-kappaB kinase/NF-kappaB cascade
- defense response to bacterium
- negative regulation of gene expression
- positive regulation of T cell cytokine production
- toll-like receptor 3 signaling pathway
- interleukin-1-mediated signaling pathway
- TRIF-dependent toll-like receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- histone kinase activity
- protein serine/threonine kinase activity
- type II transforming growth factor beta receptor binding
- MAP kinase kinase kinase kinase activity
- transcription coactivator binding
- magnesium ion binding
- ATP binding
- scaffold protein binding
- ubiquitin protein ligase binding
- protein binding
- MAP kinase activity
- MAP kinase kinase kinase activity
- receptor tyrosine kinase binding