Slc12a3 Gene Summary [Mouse]
Enables sodium:chloride symporter activity. Involved in response to aldosterone; response to salt; and sodium ion transmembrane transport. Located in apical plasma membrane and cytosol. Is active in plasma membrane. Is expressed in metanephros. Used to study Gitelman syndrome. Human ortholog(s) of this gene implicated in Gitelman syndrome and essential hypertension. Orthologous to human SLC12A3 (solute carrier family 12 member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc12a3 |
| Official Name | solute carrier family 12, member 3 [Source:MGI Symbol;Acc:MGI:108114] |
| Ensembl ID | ENSMUSG00000031766 |
| Bio databases IDs | |
| Aliases | solute carrier family 12, member 3 |
| Synonyms | AI035291, LOC100039113, LOC102553442, NCC, NCCT, solute carrier family 12 member 3, solute carrier family 12, member 3, TSC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc12a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sodium:chloride symporter
- Amino acid permease N-terminal
- sodium ion transporter
- amino acid permease
- enzyme binding
- protein binding
- transporter
- Solute carrier family 12
- K-Cl cotransporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- obstructive sleep apnea
- disorder of coronary artery
- acute kidney injury
- metabolic syndrome X
- hypertension
- Gitelman syndrome
- liver cirrhosis
- essential hypertension
- breast carcinoma
role in cell
- phosphorylation in
- production in
- tyrosine phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- vesicles
- cytosol
- apical membrane
- apical vesicles
- brush border
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc12a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- renal sodium ion absorption
- sodium ion transport
- ion transport
- potassium ion homeostasis
- chloride ion homeostasis
- signal transduction
- sodium ion homeostasis
- sodium ion transmembrane transport
- response to dietary excess
- cell volume homeostasis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- cytosol
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- sodium:chloride symporter activity
- protein binding
- sodium:potassium:chloride symporter activity