Kcnk3 Gene Summary [Mouse]
Predicted to enable S100 protein binding activity and potassium channel activity. Involved in detection of hypoxic conditions in blood by carotid body chemoreceptor signaling and regulation of action potential firing rate. Predicted to be active in plasma membrane. Is expressed in early conceptus; heart; and secondary oocyte. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Orthologous to human KCNK3 (potassium two pore domain channel subfamily K member 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnk3 |
| Official Name | potassium channel, subfamily K, member 3 [Source:MGI Symbol;Acc:MGI:1100509] |
| Ensembl ID | ENSMUSG00000049265 |
| Bio databases IDs | |
| Aliases | potassium channel, subfamily K, member 3 |
| Synonyms | cTBAK-1, K2p3.1, OAT1, potassium channel, subfamily K, member 3, potassium two pore domain channel subfamily K member 3, PPH4, rTASK, TASK, TASK-1, TBAK1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnk3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- open rectifier potassium channel
- outward rectifier potassium channel
- sodium channel
- channel/pore class transporter
- protein binding
- ion channel
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- stroke
- chronic obstructive pulmonary disease
- coronary disease
- disorder of coronary artery
- diabetes mellitus
- COVID-19
- heart disease
- metabolic syndrome X
- heart failure
regulates
- aldosterone
- KCNK3
- K+
- renin
- catecholamine
- ion
role in cell
- cell death
- growth
- excitation
- action potential
- response by
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- membrane surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnk3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- potassium ion transmembrane transport
- cellular response to zinc ion
- cochlea development
- regulation of resting membrane potential
- ion transmembrane transport
- reduction of cytosolic calcium ion concentration
- synaptic transmission
- response to xenobiotic stimulus
- cellular response to hypoxia
- stabilization of membrane potential
Cellular Component
Where in the cell the gene product is active
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ion channel activity
- outward rectifier potassium channel activity
- open rectifier potassium channel activity
- potassium channel activity
- S100 protein binding
- potassium ion leak channel activity