Casz1 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of cell differentiation and retina morphogenesis in camera-type eye. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Used to study chromosome 1p36 deletion syndrome. Orthologous to human CASZ1 (castor zinc finger 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Casz1 |
| Official Name | castor zinc finger 1 [Source:MGI Symbol;Acc:MGI:1196251] |
| Ensembl ID | ENSMUSG00000028977 |
| Bio databases IDs | |
| Aliases | castor zinc finger 1 |
| Synonyms | 2410019P08RIK, BC035954, CAS11, castor zinc finger 1, CST, D4Ertd432e, dJ734G22.1, LOC100041755, LOC100044758, RGD1563533, SRG, ZNF693 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Casz1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- double-stranded DNA binding
- nucleic acid binding
- enzyme
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- adenoma formation
- tumorigenesis
- acute myeloid leukemia
- breast carcinoma
- atrial fibrillation
- cataract
- hypertension
- uterine leiomyoma
- leiomyomatosis
role in cell
- expression in
- differentiation
- apoptosis
- proliferation
- colony formation
- commitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Casz1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- regulation of neuron differentiation
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity