Copb1 Gene Summary [Mouse]
Predicted to enable structural molecule activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and intra-Golgi vesicle-mediated transport. Located in COPI-coated vesicle and Golgi apparatus. Is expressed in neocortex; sensory organ; and skeleton. Orthologous to human COPB1 (COPI coat complex subunit beta 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Copb1 |
| Official Name | coatomer protein complex, subunit beta 1 [Source:MGI Symbol;Acc:MGI:1917599] |
| Ensembl ID | ENSMUSG00000030754 |
| Bio databases IDs | |
| Aliases | coatomer protein complex, subunit beta 1 |
| Synonyms | 2610019B04Rik, BARMACS, beta COP, coatomer protein complex, subunit beta 1, coatomer protein complex, subunit β 1, COPB, COPI coat complex subunit beta 1, COPI coat complex subunit β 1, COPII, β COP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Copb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Coatomer beta C-terminal region
- Coatomer beta subunit appendage platform
- protein binding
- Adaptin N terminal region
- transporter
Pathways
Biological processes and signaling networks where the Copb1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- metastasis
- neonatal late-onset sepsis
- Baralle-Macken syndrome
- organismal death
- COVID-19
- infection by vesicular stomatitis virus
- infection by lymphocytic choriomeningitis virus
- infection by Human parainfluenza virus 3
- infection by severe acute respiratory syndrome coronavirus 2
role in cell
- degradation in
- invasion by
- adhesion
- replication in
- vesicle transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- intracellular membrane-bounded organelle
- perinuclear region
- Plasma Membrane
- vesicles
- Golgi Apparatus
- membrane compartment
- secretory granule membrane
- tertiary granule membrane
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- Golgi buds
- cis Golgi networks
- transport vesicles
- perinuclear vesicles
- apical vesicles
- Golgi vesicles
- clathrin-coated vesicles
- cis Golgi cisternae
- trans Golgi cisternae
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Copb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- intra-Golgi vesicle-mediated transport
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- Golgi apparatus
- endoplasmic reticulum-Golgi intermediate compartment
- Golgi-associated vesicle
- plasma membrane
- endoplasmic reticulum membrane
- secretory granule membrane
- intracellular membrane-bounded organelle
- membrane
- cytosol
- transport vesicle
- tertiary granule membrane
- COPI vesicle coat
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity