Aftph Gene Summary [Mouse]
Predicted to enable clathrin binding activity. Predicted to be involved in intracellular transport. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of AP-1 adaptor complex. Predicted to be active in trans-Golgi network membrane. Orthologous to human AFTPH (aftiphilin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aftph |
| Official Name | aftiphilin [Source:MGI Symbol;Acc:MGI:1923012] |
| Ensembl ID | ENSMUSG00000049659 |
| Bio databases IDs | |
| Aliases | aftiphilin |
| Synonyms | 9130023F12RIK, aftiphilin, AU015099, AU016543, AU044244, FLJ20080, Nbla10388, RGD1311920 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aftph often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- clathrin box motif
- clathrin binding
- protein binding
- Clathrin-binding box of Aftiphilin, vesicle trafficking
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Golgi Apparatus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aftph gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular transport
- protein transport
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- intracellular membrane-bounded organelle
- AP-1 adaptor complex
- cytosol
- Golgi apparatus
- trans-Golgi network membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- clathrin binding