Vapb Gene Summary [Mouse]
Predicted to enable several functions, including FFAT motif binding activity; protein dimerization activity; and tubulin binding activity. Predicted to be involved in several processes, including IRE1-mediated unfolded protein response; endoplasmic reticulum organization; and modulation by host of viral genome replication. Located in membrane. Is expressed in dorsal root ganglion. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Orthologous to human VAPB (VAMP associated protein B and C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vapb |
| Official Name | vesicle-associated membrane protein, associated protein B and C [Source:MGI Symbol;Acc:MGI:1928744] |
| Ensembl ID | ENSMUSG00000054455 |
| Bio databases IDs | |
| Aliases | vesicle-associated membrane protein, associated protein B and C |
| Synonyms | ALS8, D2Abb2e, Vamp33b, VAMP associated protein B and C, VAMP-ASSOCIATED protein of 33 KDA, VAMP-B, VAP33b, vesicle-associated membrane protein, associated protein B and C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vapb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- microtubule binding
- cytoplasmic domain
- transmembrane domain
- enzyme binding
- protein homodimerization
- coiled-coil domain
- protein domain specific binding
- protein binding
- MSP (Major sperm protein) domain
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- tremor
- organismal death
- hypotonia
- amyotrophic lateral sclerosis
- amyotrophic lateral sclerosis 8
- Waldenström macroglobulinemia
- spinal muscular atrophy proximal adult dominant
- motor neuron disease
- autosomal dominant amyotrophic lateral sclerosis
regulates
- Ca2+
- cholesterol
- actin
- YIF1A
- MIR196A
- CARTS
- mir-221 (includes others)
- mir-484
- MIRLET7A
- diacylglycerol
role in cell
- formation in
- expression in
- cell death
- proliferation
- differentiation
- attachment
- organization
- restructuring
- restructuring in
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- glutaminergic synapse
- endoplasmic reticulum mitochondria contact site
- Cytoplasm
- presynaptic regions
- postsynaptic region
- cellular membrane
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- dendrite initial segments
- cytoplasmic vesicles
- peroxisomes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vapb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- endoplasmic reticulum membrane organization
- COPII-coated vesicle budding
- endoplasmic reticulum unfolded protein response
- positive regulation of viral genome replication
- cholesterol transport
- endoplasmic reticulum organization
- cellular calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- Golgi apparatus
- endoplasmic reticulum
- endoplasmic reticulum exit site
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- protein heterodimerization activity
- cadherin binding
- beta-tubulin binding
- FFAT motif binding
- microtubule binding
- enzyme binding