Zfp366 Gene Summary [Mouse]
Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; nuclear estrogen receptor binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of transcription by RNA polymerase II; and response to estrogen. Located in nucleus. Used to study DiGeorge syndrome. Orthologous to human ZNF366 (zinc finger protein 366). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp366 |
| Official Name | zinc finger protein 366 [Source:MGI Symbol;Acc:MGI:2178429] |
| Ensembl ID | ENSMUSG00000050919 |
| Bio databases IDs | |
| Aliases | zinc finger protein 366 |
| Synonyms | DC-SCRIPT, Zfp366, zinc finger protein 366 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp366 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- Zinc-finger double domain
- transcription co-repressor
- protein binding
- zinc finger domain
- estrogen receptor binding
- acidic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- open-angle glaucoma
- refractive error
- rheumatoid arthritis
- venous thromboembolism
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- androgenic alopecia
role in cell
- expression in
- phosphorylation in
- production in
- binding in
- transcription in
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp366 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- response to estrogen stimulus
- negative regulation of intracellular estrogen receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- transcription corepressor activity
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- estrogen receptor binding