Usp42 Gene Summary [Mouse]
Enables cysteine-type deubiquitinase activity. Involved in protein deubiquitination. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; eye; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human USP42 (ubiquitin specific peptidase 42). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp42 |
| Official Name | ubiquitin specific peptidase 42 [Source:MGI Symbol;Acc:MGI:1924050] |
| Ensembl ID | ENSMUSG00000051306 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 42 |
| Synonyms | 2410140K03RIK, 3110031A07Rik, A630018G05RIK, D5Ertd591e, ubiquitin specific peptidase 42 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Usp42 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins
- Family of unknown function (DUF5585)
- peptidase
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- protein binding
- Peptidase_C19
Pathways
Biological processes and signaling networks where the Usp42 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Usp42 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- spermatogenesis
- proteolysis
- cell differentiation
- regulation of apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding