Usp29 Gene Summary [Mouse]
Enables cysteine-type endopeptidase activity. Involved in several processes, including positive regulation of type I interferon-mediated signaling pathway; protein K48-linked deubiquitination; and protein stabilization. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; limb bud; testis; and trunk. Orthologous to human USP29 (ubiquitin specific peptidase 29). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Usp29 |
| Official Name | ubiquitin specific peptidase 29 [Source:MGI Symbol;Acc:MGI:1888998] |
| Ensembl ID | ENSMUSG00000051527 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 29 |
| Synonyms | HOM-TES-84/86, LOC102547903, Ocat, ubiquitin specific peptidase 29 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Usp29 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine endopeptidase
- peptidase
- N-terminal of ubiquitin carboxyl-terminal hydrolase 37
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- protein binding
- Pleckstrin homology-like domain
- Peptidase_C19
Pathways
Biological processes and signaling networks where the Usp29 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- TNF
- TGF beta
- 4-phenylbutyric acid
disease
- neoplasia
- cancer
- gastric cancer
- Burkitt lymphoma
- neuroblastoma formation
role in cell
- migration
- consumption in
- proliferation
- degradation in
- phosphorylation in
- ubiquitination in
- polyubiquitination in
- deubiquitination in
- K63 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Usp29 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- innate immune response
- G1/S transition of mitotic cell cycle
- positive regulation of type I interferon-mediated signaling pathway
- proteolysis
- defense response to virus
- protein stabilization
- protein K48-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- cysteine-type endopeptidase activity