Usp29 Gene Summary [Rat]
Predicted to enable cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; positive regulation of type I interferon-mediated signaling pathway; and protein K48-linked deubiquitination. Predicted to be active in cytosol and nucleus. Orthologous to human USP29 (ubiquitin specific peptidase 29). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp29 |
| Official Name | ubiquitin specific peptidase 29 [Source:RGD Symbol;Acc:1306648] |
| Ensembl ID | ENSRNOG00000015956 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 29 |
| Synonyms | HOM-TES-84/86, LOC102547903, Ocat, ubiquitin specific peptidase 29 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Usp29 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine endopeptidase
- peptidase
- N-terminal of ubiquitin carboxyl-terminal hydrolase 37
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- protein binding
- Pleckstrin homology-like domain
- Peptidase_C19
Pathways
Biological processes and signaling networks where the Usp29 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- TNF
- TGF beta
- 4-phenylbutyric acid
disease
- neoplasia
- cancer
- gastric cancer
- Burkitt lymphoma
- neuroblastoma formation
role in cell
- migration
- consumption in
- proliferation
- degradation in
- phosphorylation in
- ubiquitination in
- polyubiquitination in
- deubiquitination in
- K63 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Usp29 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- innate immune response
- G1/S transition of mitotic cell cycle
- positive regulation of type I interferon-mediated signaling pathway
- proteolysis
- defense response to virus
- protein stabilization
- protein K48-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- cysteine-type endopeptidase activity