B3glct Gene Summary [Mouse]
Enables glycosyltransferase activity. Involved in protein O-linked fucosylation. Acts upstream of or within several processes, including cilium assembly; protein secretion; and roof of mouth development. Is active in endoplasmic reticulum membrane. Is expressed in cornea; hyaloid vascular plexus; lens; lens vesicle; and retina. Used to study Peters plus syndrome. Human ortholog(s) of this gene implicated in Peters plus syndrome. Orthologous to human B3GLCT (beta 3-glucosyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | B3glct |
| Official Name | beta-3-glucosyltransferase [Source:MGI Symbol;Acc:MGI:2685903] |
| Ensembl ID | ENSMUSG00000051950 |
| Bio databases IDs | |
| Aliases | beta-3-glucosyltransferase |
| Synonyms | B3GALTL, B3galtl-ps1, B3GTL, beta3Glc-T, beta-3-glucosyltransferase, Gal-T, Gm1057, β-3-glucosyltransferase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse B3glct often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- galactosyltransferase
- enzyme
- glycosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertelorism
- insomnia
- brachydactyly
- Peters plus syndrome
- major depression
- hydrocephalus
- age-related macular degeneration
- COVID-19
- bipolar I disorder
- cleft palate
regulated by
role in cell
- assembly
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse B3glct gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein O-linked fucosylation
- fucose metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- transferase activity, transferring glycosyl groups
- acetylglucosaminyltransferase activity