Adamts1 Gene Summary [Mouse]
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family and preproprotein that is proteolytically processed to generate a mature protein product. This secreted protein product plays an important role in ovulation, likely through its cleavage of the extracellular matrix component versican. The encoded protein may enhance tumorigenesis in a mouse model of breast cancer. Homozygous knockout mice for this gene exhibit enhanced perinatal lethality, impaired growth and adipose tissue development, and impaired ovulation in females. [provided by RefSeq, Oct 2015]
Details
| Type | Protein Coding |
| Official Symbol | Adamts1 |
| Official Name | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 [Source:MGI Symbol;Acc:MGI:109249] |
| Ensembl ID | ENSMUSG00000022893 |
| Bio databases IDs | |
| Aliases | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 |
| Synonyms | ADAM metallopeptidase with thrombospondin type 1 motif 1, ADAM metallopeptidase with thrombospondin type 1 motif, 1, ADAMTS, C3-C5, METH-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adamts1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- Reprolysin family propeptide
- extracellular domain
- thrombospondin type 1 repeat
- thrombospondin-1 motif
- ADAMTS cysteine-rich domain 2
- ADAMTS cysteine-rich domain
- metalloprotease domain
- peptidase
- protein binding
- zinc binding domain
- disintergrin domain
- metallopeptidase
- ZnMc
- ADAM-TS Spacer 1
- ADAM cysteine-rich
- Metallo-peptidase family M12B Reprolysin-like
- spacer domain
- Reprolysin (M12B) family zinc metalloprotease
- Spondin-like TSP1 domain
- heparin binding
- cysteine rich domain
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Adamts1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- neoplasia
- osteoarthritis
- epithelial cancer
- cancer
- adenoma formation
- pancreatic cancer
- non-small cell lung cancer
- metastasis
- liver cancer
role in cell
- proliferation
- quantity
- migration
- apoptosis
- activation in
- survival
- invasion by
- formation by
- tubulation by
- shedding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytoplasmic vesicles
- extracellular matrix
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adamts1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ovulation from ovarian follicle
- negative regulation of angiogenesis
- integrin-mediated signaling pathway
- positive regulation of G1/S transition of mitotic cell cycle
- kidney development
- negative regulation of cell proliferation
- proteolysis
- extracellular matrix organization
- heart trabecula formation
Cellular Component
Where in the cell the gene product is active
- basement membrane
- cytoplasmic vesicle
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- heparin binding
- metalloendopeptidase activity
- metallopeptidase activity