Tmem25 Gene Summary [Mouse]
Involved in negative regulation of excitatory postsynaptic potential and regulation of protein stability. Located in late endosome and lysosome. Is expressed in basioccipital bone; orbito-sphenoid; and temporal bone petrous part. Orthologous to human TMEM25 (transmembrane protein 25). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Tmem25 |
| Official Name | transmembrane protein 25 [Source:MGI Symbol;Acc:MGI:1918937] |
| Ensembl ID | ENSMUSG00000002032 |
| Bio databases IDs | |
| Aliases | transmembrane protein 25 |
| Synonyms | 0610039J01Rik, LOC683488, transmembrane protein 25 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoglobulin domain
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
- lysosome
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein stability
- negative regulation of excitatory postsynaptic membrane potential
Cellular Component
Where in the cell the gene product is active
- late endosome
- extracellular region
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding