Doc2a Gene Summary [Mouse]
Predicted to enable calcium-dependent phospholipid binding activity and metal ion binding activity. Involved in calcium-dependent activation of synaptic vesicle fusion and regulation of calcium ion-dependent exocytosis. Acts upstream of or within spontaneous neurotransmitter secretion. Predicted to be located in cell junction; lysosome; and nuclear lumen. Predicted to be active in glutamatergic synapse. Predicted to be extrinsic component of synaptic vesicle membrane. Is expressed in cerebral cortex. Orthologous to human DOC2A (double C2 domain alpha). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Doc2a |
| Official Name | double C2, alpha [Source:MGI Symbol;Acc:MGI:109446] |
| Ensembl ID | ENSMUSG00000052301 |
| Bio databases IDs | |
| Aliases | double C2, alpha |
| Synonyms | Doc2, Doc2 alpha, Doc2 α, double C2, alpha, double C2 domain alpha, double C2 domain α, double C2, α |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Doc2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C2-like domain
- Munc-13 binding domain
- TCTEX1 interacting domain
- protein binding
- Protein kinase C conserved region 2 (CalB)
- transporter
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- glutaminergic synapse
- cell junction
- cellular membrane
- Nucleus
- lysosome
- nucleoplasm
- nucleoli
- synaptic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Doc2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nervous system development
- synaptic transmission
- regulation of calcium ion-dependent exocytosis
- exocytosis
Cellular Component
Where in the cell the gene product is active
- cell junction
- synapse
- nucleolus
- neuron projection
- lysosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- calcium-dependent phospholipid binding