Ctsd Gene Summary [Mouse]
Enables aspartic-type endopeptidase activity. Involved in insulin catabolic process and insulin receptor recycling. Acts upstream of or within autophagosome assembly. Located in extracellular space and lysosome. Is active in endosome lumen. Is expressed in several structures, including central nervous system; extraembryonic component; eye; genitourinary system; and lung. Used to study neuronal ceroid lipofuscinosis 10. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Orthologous to human CTSD (cathepsin D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctsd |
| Official Name | cathepsin D [Source:MGI Symbol;Acc:MGI:88562] |
| Ensembl ID | ENSMUSG00000007891 |
| Bio databases IDs | |
| Aliases | cathepsin D |
| Synonyms | CATD, Cathepsin D, CD, CLN10, CPSD, EAI, HEL-S-130P, LOC196214 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ctsd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Xylanase inhibitor N-terminal
- peptide binding
- peptidase
- signal peptide
- Cellular and retroviral pepsin-like aspartate proteases
- protein binding
- enzyme
- cathepsin D
- A1 Propeptide
- endopeptidase
- cysteine endopeptidase
- aspartic endopeptidase
- hydrolase
- Xylanase inhibitor C-terminal
- Eukaryotic aspartyl protease
Pathways
Biological processes and signaling networks where the Ctsd gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- breast cancer
- breast carcinoma
- gastric adenocarcinoma
- epithelial cancer
- diabetes mellitus
- cutaneous sarcoidosis
- Alzheimer disease
- seizures
- organismal death
role in cell
- apoptosis
- cell death
- molecular cleavage in
- activation in
- colony formation
- cell viability
- expression in
- degradation in
- proliferation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome fractions
- membrane fraction
- pH resistant lipid raft fraction
- multivesicular domain
- secretory granule lumen
- ficolin-1-rich granule lumen
- cell surface
- Extracellular Space
- perinuclear region
- organelle lumens
- cellular membrane
- vacuole
- Plasma Membrane
- endosomes
- vesicles
- lysosome
- granules
- cytosol
- MHC class II compartments
- endoplasmic reticulum lumen
- pre-lysosomal compartments
- endosome-lysosome compartments
- lysosome membrane
- lysosomal compartment
- endosomal compartment
- endosomal membrane
- synapse
- cytotoxic granule
- late endosomes
- cytoplasmic vesicles
- secretory vesicles
- azurophil granules
- rough endoplasmatic reticulum
- membrane rafts
- perikaryon
- Golgi vesicles
- phagosomes
- plasma
- detergent-soluble fraction
- paraspeckle-like structures
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ctsd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- autophagic vacuole assembly
- proteolysis
- positive regulation of apoptotic process
- insulin receptor recycling
- regulation of establishment of protein localization
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- lipoprotein catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- melanosome
- specific granule lumen
- endosome lumen
- membrane raft
- endosome membrane
- lysosomal lumen
- extracellular region
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- aspartic-type endopeptidase activity
- aspartic-type peptidase activity
- cysteine-type endopeptidase activity
- peptidase activity