Scgn Gene Summary [Mouse]
Predicted to enable calcium ion binding activity. Predicted to be located in extracellular region and transport vesicle membrane. Predicted to be active in several cellular components, including cytosol; dendrite; and terminal bouton. Is expressed in several structures, including brain; gonad; liver; pancreas; and stomach. Orthologous to human SCGN (secretagogin, EF-hand calcium binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scgn |
| Official Name | secretagogin, EF-hand calcium binding protein [Source:MGI Symbol;Acc:MGI:2384873] |
| Ensembl ID | ENSMUSG00000021337 |
| Bio databases IDs | |
| Aliases | secretagogin, EF-hand calcium binding protein |
| Synonyms | CALBL, DJ501N12.8, SECRET, secretagogin, EF-hand calcium binding protein, SEGN, setagin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scgn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EFh_SPARC_EC
- EF-hand, calcium binding motif
- EF-hand domain
- EF-hand, calcium binding motif, found in the hexa-EF hand proteins family
- EF-hand domain pair
- EF hand
- EFh
- EF-hand, calcium binding motif, found in CREC-EF hand family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- insulin-dependent diabetes mellitus
- lung squamous cell carcinoma
- squamous cell lung cancer
- lung carcinoma process
- renal clear cell adenocarcinoma
- renal clear cell cancer
- systemic lupus erythematosus
- colorectal cancer
regulates
- insulin
- Ca2+
- TP53
- proinsulin
- TAC1
role in cell
- proliferation
- loss
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- membrane processes
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Scgn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of long-term synaptic potentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- transport vesicle membrane
- cytoplasm
- terminal button
- cytosol
- synapse
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding