Ncapd2 Gene Summary [Mouse]
Predicted to enable histone binding activity. Involved in positive regulation of chromosome segregation and positive regulation of chromosome separation. Located in condensed nuclear chromosome and pronucleus. Part of condensin complex. Is expressed in several structures, including central nervous system; retina outer nuclear layer; and salivary gland. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 21. Orthologous to human NCAPD2 (non-SMC condensin I complex subunit D2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ncapd2 |
| Official Name | non-SMC condensin I complex, subunit D2 [Source:MGI Symbol;Acc:MGI:1915548] |
| Ensembl ID | ENSMUSG00000038252 |
| Bio databases IDs | |
| Aliases | non-SMC condensin I complex, subunit D2 |
| Synonyms | 2810406C15Rik, 2810465G24Rik, CAP-D2, CNAP1, hCAP-D2, MCPH21, mKIAA0159, non-SMC condensin I complex subunit D2, non-SMC condensin I complex, subunit D2, RGD1562596 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ncapd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- non-SMC mitotic condensation complex subunit 1
- histone binding
- nuclear localization sequence
- protein binding
- non-SMC mitotic condensation complex subunit 1, N-term
- Mitotic chromosome targeting domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- autosomal recessive primary microcephaly type 21
- lymphomagenesis
- MYC mutation positive B-cell lymphoma
- B cell cancer
- microcephaly
regulates
role in cell
- growth
- quantity
- resolution
- condensation
- segregation
- alignment
- aneuploidy
- disorganization
- association
- structure
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- basal bodies
- centrosome
- cytosol
- nuclear foci
- chromosome
- nucleoplasm
- pronucleus
- chromosomal arms
- chromatin
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ncapd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of chromosome segregation
- meiotic chromosome condensation
- mitotic chromosome condensation
Cellular Component
Where in the cell the gene product is active
- condensed chromosome
- nucleus
- cytoplasm
- membrane
- condensed chromosome, centromeric region
- nuclear chromosome
- cytosol
- condensin complex
- condensed nuclear chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding