Zfp212 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including dendrite development; general adaptation syndrome, behavioral process; and walking behavior. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; and genitourinary system. Orthologous to human ZNF212 (zinc finger protein 212). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp212 |
| Official Name | Zinc finger protein 212 [Source:MGI Symbol;Acc:MGI:2682609] |
| Ensembl ID | ENSMUSG00000052763 |
| Bio databases IDs | |
| Aliases | Zinc finger protein 212 |
| Synonyms | C2H2-150, mKIAA3011, Zfp212, Zinc finger protein 212, ZNF182, ZNFC150 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp212 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- zinc finger
- transcription regulator
- Zinc-finger double domain
- protein binding
- KRAB (Kruppel-associated box) domain -A box
- identical protein binding
- C2H2-type zinc finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- TRAIP
role in cell
- apoptosis
- formation
- development
- formation in
- sister chromatid exchange in
- hydroxyurea sensitivity
- camptothecin sensitivity
- homologous recombination repair in
- mitomycin C sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp212 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to alcohol
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- general adaptation syndrome, behavioral process
- neuromuscular process controlling balance
- neuron apoptotic process
- regulation of transcription from RNA polymerase II promoter
- dendrite development
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- sequence-specific DNA binding transcription factor activity
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription