Smarca2 Gene Summary [Mouse]
Predicted to enable several functions, including chromatin binding activity; nucleosome array spacer activity; and transcription coactivator activity. Acts upstream of or within aortic smooth muscle cell differentiation; hematopoietic stem cell homeostasis; and negative regulation of fibroblast proliferation. Located in nucleus. Part of nBAF complex and npBAF complex. Is expressed in several structures, including early conceptus; genitourinary system; heart; telencephalon; and vitelline artery. Human ortholog(s) of this gene implicated in Nicolaides-Baraitser syndrome and blepharophimosis-impaired intellectual development syndrome. Orthologous to human SMARCA2 (SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smarca2 |
| Official Name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 [Source:MGI Symbol;Acc:MGI:99603] |
| Ensembl ID | ENSMUSG00000024921 |
| Bio databases IDs | |
| Aliases | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 |
| Synonyms | 2610209L14RIK, BAF190, BIS, brahma, BRM, BRM1, hBRM, hSNF2a, NCBRS, SNF2, SNF2alpha, SNF2L2, SNF2LA, Sth1p, SWI2, SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Smarca2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Snf2-ATP coupling, chromatin remodelling complex
- transcription regulator
- transcription co-activator
- helicase
- chromatin binding
- LXCXE binding site
- Bromodomain
- Helicase conserved C-terminal domain
- retinoblastoma protein binding domain
- QLQ
- helicase domain
- BRK domain
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
- proline/glutamine rich region
- domain in helicases and associated with SANT domains
- nucleic acid binding
- NTP binding domain
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- SNF2-related domain
- protein binding
- DNA dependent ATPase
- HSA domain
- sequence-specific DNA binding
- double-stranded DNA binding
Pathways
Biological processes and signaling networks where the Smarca2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Waldenström macroglobulinemia
- neoplasia
- blepharophimosis-impaired intellectual development syndrome
- Nicolaides-Baraitser syndrome
- cancer
- estrogen receptor-negative breast cancer
- mental retardation
- hereditary disorder
- gastric epithelial cancer
- severe acute respiratory syndrome
role in cell
- expression in
- apoptosis
- growth
- formation
- survival
- G1 phase
- binding in
- differentiation
- translation in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- nuclear matrix fraction
- interzone
- intermediate filament cytoskeleton
- intracellular membrane-bounded organelle
- Cytoplasm
- cellular membrane
- nucleoplasm
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Smarca2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitotic metaphase/anaphase transition
- spermatid development
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- nervous system development
- regulation of transcription, DNA-dependent
- positive regulation of cell differentiation
- positive regulation of myoblast differentiation
- regulation of nucleotide-excision repair
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- negative regulation of cell differentiation
- negative regulation of cell growth
- positive regulation of transcription, DNA-dependent
- positive regulation of T cell differentiation
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of double-strand break repair
- regulation of G0 to G1 transition
Cellular Component
Where in the cell the gene product is active
- nucleus
- SWI/SNF complex
- intermediate filament cytoskeleton
- npBAF complex
- intracellular membrane-bounded organelle
- brahma complex
- nBAF complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- DNA binding
- DNA-dependent ATPase activity
- protein binding
- transcription coactivator activity
- histone binding
- transcription regulatory region sequence-specific DNA binding
- helicase activity
- chromatin binding
- hydrolase activity