Sf3a3 Gene Summary [Mouse]
Predicted to enable RNA binding activity. Predicted to be involved in U2-type prespliceosome assembly. Predicted to be located in nuclear speck. Predicted to be part of U2 snRNP; U2-type precatalytic spliceosome; and catalytic step 2 spliceosome. Is expressed in several structures, including central nervous system; hemolymphoid system; liver; muscle tissue; and sensory organ. Orthologous to human SF3A3 (splicing factor 3a subunit 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sf3a3 |
| Official Name | splicing factor 3a, subunit 3 [Source:MGI Symbol;Acc:MGI:1922312] |
| Ensembl ID | ENSMUSG00000028902 |
| Bio databases IDs | |
| Aliases | splicing factor 3a, subunit 3 |
| Synonyms | 4930512K19Rik, LRRGT00093, PRP9, PRPF9, SAP61, SF3a60, splicing factor 3a subunit 3, splicing factor 3a, subunit 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sf3a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SF3a60/Prp9 C-terminal
- Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9
- protein binding
- zinc finger domain
- Splicing factor SF3a60 binding domain
- Replication stress response SDE2 C-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- thyroiditis
- non-small cell lung cancer
role in cell
- cell viability
- expression in
- growth
- phosphorylation in
- splicing by
- alternative splicing in
- processing in
- homologous recombination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- catalytic step 2 spliceosome
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
- nuclear speckles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sf3a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing, via transesterification reactions
- mRNA processing
- nuclear mRNA 3'-splice site recognition
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- nuclear speck
- spliceosomal complex
- U2-type spliceosomal complex
- U2-type precatalytic spliceosome
- U2 snRNP
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- RNA binding