Cyp2f2 Gene Summary [Mouse]
Predicted to enable arachidonate epoxygenase activity; heme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within naphthalene catabolic process and response to toxic substance. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; nose; pharyngo-tympanic tube; respiratory system; and sublingual gland primordium. Orthologous to several human genes including CYP2F1 (cytochrome P450 family 2 subfamily F member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp2f2 |
| Official Name | cytochrome P450, family 2, subfamily f, polypeptide 2 [Source:MGI Symbol;Acc:MGI:88608] |
| Ensembl ID | ENSMUSG00000052974 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 2, subfamily f, polypeptide 2 |
| Synonyms | C2F1, CYP2F, Cyp2f2, CYPIIF1, cytochrome P450 family 2 subfamily F member 1, cytochrome P450, family 2, subfamily f, polypeptide 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyp2f2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- oxygen binding
- reduced flavin or flavoprotein:oxygen oxidoreductase
- unspecific monooxygenase
- monooxygenase
- enzyme
Pathways
Biological processes and signaling networks where the Cyp2f2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
- adenoma formation
- pituitary gland adenoma
- head and neck neuroendocrine neoplasia
regulates
- 2-methylnaphthalene
- naphthalene
- coumarin
- 7-pentoxyresorufin
- ethoxyresorufin
- 1-nitronaphthalene
- 1-nitronaphthalene-5,6-epoxide
- anthracene
- xenobiotic
- 1-nitronaphthalene-7,8-epoxide
role in cell
- cell death
- apoptosis
- adipogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cyp2f2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epoxygenase P450 pathway
- xenobiotic metabolic process
- response to toxin
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- intracellular membrane-bounded organelle
Molecular Function
What the gene product does at the molecular level
- oxygen binding
- arachidonic acid epoxygenase activity
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
- iron ion binding
- aromatase activity
- monooxygenase activity
- heme binding