Zbtb20 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to glucose stimulus; positive regulation of metabolic process; and regulation of gene expression. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study Alzheimer's disease. Orthologous to human ZBTB20 (zinc finger and BTB domain containing 20). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Zbtb20 |
| Official Name | zinc finger and BTB domain containing 20 [Source:MGI Symbol;Acc:MGI:1929213] |
| Ensembl ID | ENSMUSG00000022708 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 20 |
| Synonyms | 1300017A20Rik, 7330412A13RIK, A930017C21Rik, D16Wsu73e, DKFZp566F123, DPZF, HOF, J20, LOC102723469, Oda8, ODA-8S, PRIMS, RGD1560387, Tg(PDGFB-APPSwInd)20Lms, Zfp288, zinc finger and BTB domain containing 20, ZNF288 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zbtb20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- nucleic acid binding
- BTB_POZ
- sequence-specific DNA binding
- C2H2-type zinc finger
- DNA binding
- zinc finger
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- Broad-Complex, Tramtrack and Bric a brac
- Zinc-finger double domain
- BTB/POZ domain
- zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- abdominal cancer
- cancer
- epithelial cancer
- COVID-19
- mental retardation
- Primrose syndrome
- bipolar disorder
- major depression
- hereditary disorder
- metabolic syndrome X
role in cell
- production in
- expression in
- survival
- activation in
- invasion by
- growth
- cell cycle progression
- number
- area
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nuclear bodies
- interchromatin granule clusters
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zbtb20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- cellular response to glucose stimulus
- positive regulation of interferon-beta production
- lipid homeostasis
- positive regulation of tumor necrosis factor production
- regulation of cytokine production
- positive regulation of interleukin-6 production
- regulation of immune system process
- positive regulation of glycolysis
- positive regulation of lipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription