Nodal Gene Summary [Mouse]
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. Homozygous knockout mice for this gene exhibit early embryonic lethality, while expression of a hypomorphic allele results in defects in anteroposterior and left-right patterning. [provided by RefSeq, Aug 2016]
Details
| Type | Protein Coding |
| Official Symbol | Nodal |
| Official Name | nodal [Source:MGI Symbol;Acc:MGI:97359] |
| Ensembl ID | ENSMUSG00000037171 |
| Bio databases IDs | |
| Aliases | nodal |
| Synonyms | HTX5, IV, nodal growth differentiation factor, Tg.413d |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nodal often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycoprotein hormone beta chain homologues
- TGF_beta_SF
- Transforming growth factor beta like domain
- receptor agonist activity
- protein binding
- receptor binding
- cytokine
- growth factor
Pathways
Biological processes and signaling networks where the Nodal gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- colorectal cancer
- organismal death
- autosomal 5 visceral heterotaxy
- Parkinson disease
- hereditary disorder
- situs ambiguus
- hereditary Wolff-Parkinson-White syndrome
role in cell
- proliferation
- expression in
- apoptosis
- cell death
- inhibition in
- growth
- differentiation
- phosphorylation in
- migration
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nodal gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- polarity specification of proximal/distal axis
- left lung morphogenesis
- positive regulation of cell-cell adhesion
- transforming growth factor beta receptor signaling pathway
- inhibition of neuroepithelial cell differentiation
- epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- placenta development
- formation of anatomical boundary
- positive regulation of angiogenesis
- embryonic placenta development
- negative regulation of androgen receptor signaling pathway
- maternal placenta development
- nodal signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- neural fold formation
- liver development
- vasculature development
- positive regulation of activin receptor signaling pathway
- somatic stem cell maintenance
- regulation of stem cell maintenance
- heart looping
- positive regulation of SMAD protein import into nucleus
- mesendoderm development
- positive regulation of epithelial cell proliferation
- positive regulation vascular endothelial growth factor production
- germ cell development
- regulation of gastrulation
- embryonic pattern specification
- determination of left/right asymmetry in lateral mesoderm
- axial mesodermal cell fate specification
- embryonic cranial skeleton morphogenesis
- digestive tract morphogenesis
- brain development
- embryonic process involved in female pregnancy
- maternal process involved in parturition
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- floor plate morphogenesis
- trophectodermal cellular morphogenesis
- cell migration involved in gastrulation
- positive regulation of ERK1 and ERK2 cascade
- endodermal cell differentiation
- negative regulation of cell development
- primitive streak formation
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- type I activin receptor binding
- cytokine activity
- morphogen activity