Pom121 Gene Summary [Mouse]
Predicted to enable nuclear localization sequence binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in RNA export from nucleus; nuclear pore organization; and protein import into nucleus. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be part of nuclear pore. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; integumental system; and nervous system. Orthologous to several human genes including POM121 (POM121 transmembrane nucleoporin) and POM121C (POM121 transmembrane nucleoporin C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pom121 |
| Official Name | nuclear pore membrane protein 121 [Source:MGI Symbol;Acc:MGI:2137624] |
| Ensembl ID | ENSMUSG00000053293 |
| Bio databases IDs | |
| Aliases | nuclear pore membrane protein 121 |
| Synonyms | 2610027A18Rik, LOC340318, LOC441253, mKIAA0618, nuclear pore membrane protein 121, Pom121, POM121-2, POM121 transmembrane nucleoporin, POM121 transmembrane nucleoporin C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pom121 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of nuclear pore
- nuclear localization sequence
- POM121 family
- protein binding
Pathways
Biological processes and signaling networks where the Pom121 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- obesity
- essential hypertension
- hypertension
- systemic lupus erythematosus
- metabolic syndrome X
- morbid obesity
- overnutrition
regulates
- POM121C
- HEH2
role in cell
- accumulation in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cellular membrane
- nuclear pores
- inner nuclear membrane
- nucleoplasm
- nuclear rim
- nuclear envelope
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pom121 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA export from nucleus
- protein import into nucleus
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- endoplasmic reticulum membrane
- nuclear membrane
- nuclear pore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of nuclear pore
- nuclear localization sequence binding