Cul4b Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase binding activity. Predicted to contribute to damaged DNA binding activity. Involved in several processes, including astrocyte differentiation; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Acts upstream of or within positive regulation of G1/S transition of mitotic cell cycle and positive regulation of protein catabolic process. Part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex. Is expressed in brain; cerebral cortex; cerebral cortex ventricular layer; and liver. Used to study intellectual disability. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Cabezas type. Orthologous to human CUL4B (cullin 4B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cul4b |
| Official Name | cullin 4B [Source:MGI Symbol;Acc:MGI:1919834] |
| Ensembl ID | ENSMUSG00000031095 |
| Bio databases IDs | |
| Aliases | cullin 4B |
| Synonyms | 2700050M05Rik, CULB4, cullin 4B, KIAA0695, mKIAA0695, MRSS, MRXHF2, MRXS15, MRXSC, RGD1564494, SFM2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cul4b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- damaged DNA binding
- Cullin protein neddylation domain
- Cullin family
- protein binding
- Cullin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- neoplasia
- tumorigenesis
- bladder cancer
- metastasis
- organismal death
- X-linked mental retardation with short stature
- growth failure
role in cell
- binding in
- apoptosis
- expression in
- proliferation
- number
- production in
- degradation in
- upregulation in
- loss
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cul4b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- astrocyte differentiation
- UV-damage excision repair
- positive regulation of G1/S transition of mitotic cell cycle
- neuron projection development
- protein polyubiquitination
- positive regulation of protein catabolic process
- ribosome biogenesis
- response to DNA damage stimulus
- ubiquitin-dependent protein catabolic process
- G1/S transition of mitotic cell cycle
- cellular response to UV
- gene expression
- protein ubiquitination
- proteasomal protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- Cul4A-RING ubiquitin ligase complex
- cytosol
- Cul4B-RING ubiquitin ligase complex
- CUL4 RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- protein binding
- damaged DNA binding