Ugt2b5 Gene Summary [Mouse]
Predicted to enable glucuronosyltransferase activity. Predicted to be involved in estrogen metabolic process. Located in mitochondrial inner membrane. Orthologous to several human genes including UGT2B10 (UDP glucuronosyltransferase family 2 member B10); UGT2B11 (UDP glucuronosyltransferase family 2 member B11); and UGT2B15 (UDP glucuronosyltransferase family 2 member B15). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ugt2b5 |
| Official Name | UDP glucuronosyltransferase 2 family, polypeptide B5 [Source:MGI Symbol;Acc:MGI:98900] |
| Ensembl ID | ENSMUSG00000054630 |
| Bio databases IDs | |
| Aliases | UDP glucuronosyltransferase 2 family, polypeptide B5 |
| Synonyms | 0610033E06Rik, 9430041C03Rik, Androsterone UDP-glucuronosyltransferase, LOC688226, M-1, UDP-Glucuronosyl-Transferase 2 Family, UDP glucuronosyltransferase 2 family, polypeptide B37, UDP glucuronosyltransferase 2 family, polypeptide B38, UDP glucuronosyltransferase 2 family, polypeptide B5, UDP glucuronosyltransferase family 2 member B28, UDP glycosyltransferase 2 family, polypeptide B, UDPGT, Udpgt-2b, UDPGT 2B5, Udpgt-3, UGT2, Ugt2b, Ugt2b17, Ugt2b2, Ugt2b37, Ugt2b38, Ugt2b5, Ugt2b7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ugt2b5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycosyltransferase family 1 and related proteins with GTB topology
- glycosyltransferase, MGT family
- enzyme
- UDP-glucoronosyl and UDP-glucosyl transferase
- glucuronosyltransferase
Pathways
Biological processes and signaling networks where the Ugt2b5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- beta-estradiol
- testosterone
- etiocholanolone
- steroid
- 5-beta-androstane 3 alpha, 17-beta diol
- 1-naphthol
- hymecromone
- androsterone
- eugenol
- 3-alpha,17-beta-androstanediol
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Endoplasmic Reticulum
- microsome
- outer nuclear membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ugt2b5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- xenobiotic glucuronidation
- estrogen metabolic process
- cellular glucuronidation
- steroid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- endoplasmic reticulum
- nuclear outer membrane
Molecular Function
What the gene product does at the molecular level
- glucuronosyltransferase activity