Atrnl1 Gene Summary [Mouse]
Predicted to enable Notch binding activity. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human ATRNL1 (attractin like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atrnl1 |
| Official Name | attractin like 1 [Source:MGI Symbol;Acc:MGI:2147749] |
| Ensembl ID | ENSMUSG00000054843 |
| Bio databases IDs | |
| Aliases | attractin like 1 |
| Synonyms | AI504415, ALP, Atrnl, Atrnlp, attractin like 1, bA338L11.1, bA454H24.1, KIAA0534, RGD1563485 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atrnl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Laminin-type epidermal growth factor-like domai
- Kelch motif
- CUB
- Plexin repeat
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- protein binding
- EGF_CA
- Delta serrate ligand
- Laminin EGF domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine leiomyoma
- leiomyomatosis
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- diabetic nephropathy
- stuttering
- osteoarthritis
- restless legs syndrome
- ovarian carcinoma
- epithelial ovarian cancer
regulated by
- NUP98-HOXA9
- topotecan
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atrnl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- Notch binding
- carbohydrate binding