Ift122

Involved in several processes, including cilium organization; embryonic morphogenesis; and protein localization to organelle. Acts upstream of or within several processes, including embryonic morphogenesis; negative regulation of keratinocyte proliferation; and non-motile cilium assembly. Located in several cellular components, including ciliary basal body; ciliary base; and photoreceptor connecting cilium. Part of intraciliary transport particle A. Is expressed in several structures, including choroid plexus; dorsal root ganglion; genitourinary system; olfactory epithelium; and pituitary gland. Human ortholog(s) of this gene implicated in cranioectodermal dysplasia 1. Orthologous to human IFT122 (intraflagellar transport 122). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ift122 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Ift122 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Ift122 gene, providing context for its role in the cell.