Appbp2 Gene Summary [Mouse]
Predicted to enable microtubule binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within intracellular transport. Predicted to be located in cytoplasmic vesicle membrane and nucleoplasm. Predicted to be part of Cul2-RING ubiquitin ligase complex. Orthologous to human APPBP2 (amyloid beta precursor protein binding protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Appbp2 |
| Official Name | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 [Source:MGI Symbol;Acc:MGI:1914134] |
| Ensembl ID | ENSMUSG00000018481 |
| Bio databases IDs | |
| Aliases | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 |
| Synonyms | 1300003O07Rik, AI465480, amyloid beta precursor protein binding protein 2, amyloid β precursor protein binding protein 2, HS.84084, KIAA0228, PAT1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Appbp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- LXXLL motif
- protein binding activity, bridging
- protein binding
- tetratricopeptide repeat
- microtubule motor protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cytoplasmic vesicle membrane
- Nucleus
- vesicles
- microtubules
- cytosol
- nucleoplasm
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Appbp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- intracellular transport
- intracellular protein transport
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic vesicle membrane
- cytoplasm
- Cul2-RING ubiquitin ligase complex
- microtubule associated complex
- microtubule
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- microtubule motor activity
- protein binding