Gabrg3 Gene Summary [Mouse]
Enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and inhibitory synapse assembly. Is active in GABA-ergic synapse and synaptic membrane. Is expressed in brain; dentate gyrus subgranular zone; dorsal striatum; lens; and ventral striatum. Orthologous to human GABRG3 (gamma-aminobutyric acid type A receptor subunit gamma3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gabrg3 |
| Official Name | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3 [Source:MGI Symbol;Acc:MGI:95624] |
| Ensembl ID | ENSMUSG00000055026 |
| Bio databases IDs | |
| Aliases | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3 |
| Synonyms | 6330406O05Rik, B230362M20RIK, gamma-aminobutyric acid type A receptor subunit gamma 3, gamma-aminobutyric acid type A receptor, subunit gamma 3, LOC105376702, LOC653227, γ-aminobutyric acid type A receptor subunit gamma3, γ-aminobutyric acid type A receptor subunit γ 3, γ-aminobutyric acid type A receptor, subunit γ 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gabrg3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GABA-A receptor
- transmembrane domain of Cys-loop neurotransmitter-gated ion channels
- channel/pore class transporter
- extracellular ligand-gated ion channel
- Cation transporter family protein
- ion channel
- anion channel
- neurotransmitter receptor
- LGIC_ECD
- Neurotransmitter-gated ion-channel transmembrane region
- Neurotransmitter-gated ion-channel ligand binding domain
- chloride channel
- ligand-gated ion channel
Pathways
Biological processes and signaling networks where the Gabrg3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- GABRA2
- histone H3
- tracazolate
- olanzapine
- muscimol
- phenobarbital
- sevoflurane
- eszopiclone
- isoflurane
- pentobarbital
disease
- infection
- plasma cell myeloma
- septic shock
- sepsis
- pneumonia
- acute renal failure
- diabetes mellitus
- chronic obstructive pulmonary disease
- epithelial ovarian cancer
- cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microtubule cytoskeleton
- cellular membrane
- synaptic membrane
- nucleoli
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gabrg3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of postsynaptic membrane potential
- response to xenobiotic stimulus
- synaptic transmission, GABAergic
- gamma-aminobutyric acid signaling pathway
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- dendrite membrane
- microtubule cytoskeleton
- postsynaptic membrane
- synapse
- nucleolus
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GABA-A receptor activity
- chloride channel activity
- benzodiazepine receptor activity
- GABA-gated chloride ion channel activity