Rad21 Gene Summary [Mouse]
Enables cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of G2/M transition of mitotic cell cycle and negative regulation of mitotic metaphase/anaphase transition. Acts upstream of or within chromatin looping. Located in chromatin; chromosome, centromeric region; and condensed nuclear chromosome. Part of cohesin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 4; endometrial cancer; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human RAD21 (RAD21 cohesin complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rad21 |
| Official Name | RAD21 cohesin complex component [Source:MGI Symbol;Acc:MGI:108016] |
| Ensembl ID | ENSMUSG00000022314 |
| Bio databases IDs | |
| Aliases | RAD21 cohesin complex component |
| Synonyms | CDLS4, hHR21, HR21, HRAD21, MCD1, MGS, mHR21, mKIAA0078, NXP1, Pw29, RAD21 cohesin complex component, SCC1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rad21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- double-stranded DNA binding
- Middle HEAT-repeat binding domain of Rad21/Rec8-like proteins
- nucleic acid binding
- N terminus of Rad21 / Rec8 like protein
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- Conserved region of Rad21 / Rec8 like protein
- RNA binding
Pathways
Biological processes and signaling networks where the Rad21 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast adenocarcinoma
- serous ovarian adenocarcinoma
- serous ovarian cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- Cornelia de Lange syndrome type 4
- urothelial bladder carcinoma
- transitional cell bladder cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
role in cell
- binding in
- apoptosis
- expression in
- survival
- phosphorylation in
- cell death
- formation
- growth
- mitosis
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- midbody
- cytosol
- chromosome
- nucleoplasm
- nuclear matrix
- mitotic spindle
- chromatin structures
- centromeres
- synaptonemal complexes
- chromatin
- plasma
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rad21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sister chromatid cohesion
- reciprocal meiotic recombination
- establishment of meiotic sister chromatid cohesion
- negative regulation of interleukin-1 beta production
- negative regulation of glial cell apoptotic process
- establishment of mitotic sister chromatid cohesion
- negative regulation of mitotic metaphase/anaphase transition
- DNA recombination
- chromosome segregation
- positive regulation of sister chromatid cohesion
- regulation of transcription from RNA polymerase II promoter
- double-strand break repair
- negative regulation of neuron apoptotic process
- cell division
- response to hypoxia
- protein localization to chromatin
- apoptotic process
- positive regulation of interleukin-10 production
- negative regulation of tumor necrosis factor production
- negative regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- spindle pole
- cohesin complex
- chromosome
- chromosome, centromeric region
- chromatin
- condensed nuclear chromosome
- nucleoplasm
- nucleus
- membrane
- nuclear matrix
- cytosol
- meiotic cohesin complex
- midbody
- mitotic cohesin complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- chromatin binding