Atp10b Gene Summary [Mouse]
Predicted to enable glycosylceramide flippase activity and phosphatidylcholine flippase activity. Predicted to be involved in lysosomal membrane organization and phospholipid translocation. Predicted to be located in endoplasmic reticulum; late endosome membrane; and lysosomal membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in plasma membrane. Orthologous to human ATP10B (ATPase phospholipid transporting 10B (putative)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Atp10b |
| Official Name | ATPase, class V, type 10B [Source:MGI Symbol;Acc:MGI:2442688] |
| Ensembl ID | ENSMUSG00000055415 |
| Bio databases IDs | |
| Aliases | ATPase, class V, type 10B |
| Synonyms | 5930426O13Rik, 9030605H24RIK, ATPase, class V, type 10B, ATPase phospholipid transporting 10B, ATPase phospholipid transporting 10B (putative), ATPVB, FLJ21477, RGD1565126 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp10b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- HAD-superfamily hydrolase, subfamily IIB
- phosphatidylcholine transporter
- phospholipid transporter
- Phospholipid-translocating ATPase N-terminal
- phospholipid-translocating P-type ATPase, flippase
- sphingolipid transporter
- protein binding
- Haloacid Dehalogenase-like Hydrolases
- transporter
- Phospholipid-translocating P-type ATPase C-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Endoplasmic Reticulum
- lysosome membrane
- endosomal membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp10b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosomal membrane organization
- phospholipid translocation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- late endosome membrane
- membrane
- endoplasmic reticulum
- plasma membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATPase activity
- ATP binding
- protein binding