Atp11a Gene Summary [Mouse]
Predicted to enable phosphatidylethanolamine flippase activity and phosphatidylserine flippase activity. Involved in positive regulation of myotube differentiation. Acts upstream of or within in utero embryonic development. Predicted to be located in Golgi apparatus. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in endoplasmic reticulum; plasma membrane; and recycling endosome. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 84 and hypomyelinating leukodystrophy 24. Orthologous to human ATP11A (ATPase phospholipid transporting 11A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp11a |
| Official Name | ATPase, class VI, type 11A [Source:MGI Symbol;Acc:MGI:1354735] |
| Ensembl ID | ENSMUSG00000031441 |
| Bio databases IDs | |
| Aliases | ATPase, class VI, type 11A |
| Synonyms | 4930558F19Rik, ATPase, class 1, member h, ATPase, class VI, type 11A, ATPase phospholipid transporting 11A, Atpc1h, ATPIH, ATPIS, ATPVIH, AUNA2, DFNA84, HLD24, Ih, UA20 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp11a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- R3H
- phospholipid transporter
- Phospholipid-translocating ATPase N-terminal
- protein binding
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- Phospholipid-translocating P-type ATPase C-terminal
- lipid transporter
- aminophospholipid transporter
- phospholipid-translocating P-type ATPase, flippase
- Cation transport ATPase (P-type)
- Haloacid Dehalogenase-like Hydrolases
- transporter
- haloacid dehalogenase-like hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- skin cancer
- squamous cell cancer
- epithelial cancer
- skin neoplasia
- interstitial lung disease
- COVID-19
- critical COVID-19
- autosomal dominant deafness type 84
- sunburn
- diabetic nephropathy
regulates
- Shiga toxin 2
- phosphatidylserine
- phosphatidylethanolamine
role in cell
- differentiation
- exposure in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- tertiary granule membrane
- specific granule membrane
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp11a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of membrane lipid distribution
- phospholipid translocation
- in utero embryonic development
- positive regulation of myotube differentiation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- early endosome
- intracellular membrane-bounded organelle
- membrane
- recycling endosome
- endoplasmic reticulum
- Golgi apparatus
- tertiary granule membrane
- lysosomal membrane
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- magnesium ion binding
- ATP binding
- protein binding