Phactr3 Gene Summary [Mouse]
Predicted to enable actin binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be located in nucleoplasm. Is expressed in several structures, including central nervous system; skeletal muscle; testis; and trunk. Orthologous to human PHACTR3 (phosphatase and actin regulator 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phactr3 |
| Official Name | phosphatase and actin regulator 3 [Source:MGI Symbol;Acc:MGI:1921439] |
| Ensembl ID | ENSMUSG00000027525 |
| Bio databases IDs | |
| Aliases | phosphatase and actin regulator 3 |
| Synonyms | 1500003N10RIK, 4930415A02RIK, C20ORF101, H17739, mKIAA4224, phosphatase and actin regulator 3, PPP1R123, SCAPIN1, SCAPININ |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Phactr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase inhibitor activity
- actin-binding domain
- RPEL repeat
- actin binding
- protein binding
- phosphorylation site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- dementia
- pediatric inflammatory bowel disease
- schizophrenia
- idiopathic pulmonary fibrosis
- refractive error
- TCF3-PBX1 fusion positive acute lymphoblastic leukemia
regulates
- PP1
role in cell
- elongation in
- elongation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- intermediate filaments
- nucleoplasm
- nuclear scaffolds
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Phactr3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- nuclear matrix
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein phosphatase inhibitor activity
- protein binding
- actin binding