Gucy2g Gene Summary [Mouse]
Enables guanylate cyclase activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; immune system; liver; and musculature. Orthologous to human GUCY2GP (guanylate cyclase 2G, pseudogene). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gucy2g |
| Official Name | guanylate cyclase 2g [Source:MGI Symbol;Acc:MGI:106025] |
| Ensembl ID | ENSMUSG00000055523 |
| Bio databases IDs | |
| Aliases | guanylate cyclase 2g |
| Synonyms | 2410077I05Rik, GC-G, guanylate cyclase 2G, Guanylyl cyclase g, ksGC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gucy2g often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Receptor family ligand binding region
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- enzyme
- Protein kinase domain
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Type 1 periplasmic binding fold superfamily
- guanylate cyclase
- Class III nucleotidyl cyclases
- Adenylyl- / guanylyl cyclase, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Gucy2g gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- acrosome plasma membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face