Mok Gene Summary [Mouse]
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Located in ciliary base and nucleus. Is expressed in brain; gonad; heart; liver; and metanephros. Orthologous to human MOK (MOK protein kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mok |
| Official Name | MOK protein kinase [Source:MGI Symbol;Acc:MGI:1336881] |
| Ensembl ID | ENSMUSG00000056458 |
| Bio databases IDs | |
| Aliases | MOK protein kinase |
| Synonyms | MOK protein kinase, RAGE, RAGE-1, STK30 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mok often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- hepatocellular carcinoma
- adenoma formation
- liver cancer
- epithelial cancer
- gastrointestinal neoplasia
- intestinal adenoma
role in cell
- proinflammatory response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cilia
- cell surface
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mok gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- regulation of cell cycle
- protein phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cilium
Molecular Function
What the gene product does at the molecular level
- ATP binding
- metal ion binding
- protein kinase activity
- cyclin-dependent protein kinase activity
- protein serine/threonine kinase activity