MOK Gene Summary [Human]
This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]
Details
| Type | Processed Transcript |
| Official Symbol | MOK |
| Official Name | MOK protein kinase [Source:HGNC Symbol;Acc:HGNC:9833] |
| Ensembl ID | ENSG00000080823 |
| Bio databases IDs | |
| Aliases | MOK protein kinase |
| Synonyms | MOK protein kinase, RAGE, RAGE-1, STK30 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MOK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- hepatocellular carcinoma
- adenoma formation
- liver cancer
- epithelial cancer
- gastrointestinal neoplasia
- intestinal adenoma
role in cell
- proinflammatory response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cilia
- cell surface
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MOK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- regulation of cell cycle
- protein phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cilium
Molecular Function
What the gene product does at the molecular level
- ATP binding
- metal ion binding
- protein kinase activity
- cyclin-dependent protein kinase activity
- protein serine/threonine kinase activity