Ttc26 Gene Summary [Mouse]
Enables intraciliary transport particle B binding activity. Involved in cilium organization; protein localization to cilium; and smoothened signaling pathway. Acts upstream of or within manchette assembly. Located in centrosome; ciliary basal body; and neuron projection. Part of intraciliary transport particle B. Is expressed in spinal cord. Orthologous to human IFT56 (intraflagellar transport 56). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ttc26 |
| Official Name | tetratricopeptide repeat domain 26 [Source:MGI Symbol;Acc:MGI:2444853] |
| Ensembl ID | ENSMUSG00000056832 |
| Bio databases IDs | |
| Aliases | tetratricopeptide repeat domain 26 |
| Synonyms | 9330141E21RIK, 9430097H08Rik, BRENS, DYF13, hop, hpy, intraflagellar transport 56, TTC26 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ttc26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein binding
- Anaphase-promoting complex, cyclosome, subunit 3
- tetratricopeptide repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- ciliary tip
- cilia
- basal bodies
- centrosome
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ttc26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intraflagellar transport
- cilium morphogenesis
- protein transport
- smoothened signaling pathway
- intraflagellar transport involved in cilium morphogenesis
- axoneme assembly
- intraflagellar anterograde transport
Cellular Component
Where in the cell the gene product is active
- centrosome
- cilium basal body
- cilium
- intraflagellar transport particle B
- neuron projection