Clec16a Gene Summary [Mouse]
Involved in protein destabilization and regulation of proteasomal ubiquitin-dependent protein catabolic process. Acts upstream of or within negative regulation of mitophagy; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of autophagosome maturation. Located in endolysosome membrane. Is expressed in islets of Langerhans. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in Addison's disease; multiple sclerosis; rheumatoid arthritis; and type 1 diabetes mellitus. Orthologous to human CLEC16A (C-type lectin domain containing 16A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clec16a |
| Official Name | C-type lectin domain family 16, member A [Source:MGI Symbol;Acc:MGI:1921624] |
| Ensembl ID | ENSMUSG00000068663 |
| Bio databases IDs | |
| Aliases | C-type lectin domain family 16, member A |
| Synonyms | 4932416N17Rik, CL16A, C-type lectin domain containing 16A, C-type lectin domain family 16, member A, curt, Gop-1, KIAA0350, mKIAA0350, RGD1305773, Riken cDNA 4932416n17 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clec16a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CLEC16A C-terminal
- Uncharacterized conserved protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck neoplasia
- non-insulin-dependent diabetes mellitus
- chronic sinusitis
- multiple sclerosis
- allergic rhinitis
- systemic lupus erythematosus
- asthma
- microscopic colitis
- IgA deficiency
- uterine leiomyoma
regulates
- proinsulin
- PRKN
- proteasome
- Shiga toxin 2
- oxygen
role in cell
- expression in
- quantity
- response
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- vesicles
- Golgi Apparatus
- cytosol
- lysosome membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clec16a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagy
- endosomal transport
- endosome to lysosome transport
- cellular response to starvation
Cellular Component
Where in the cell the gene product is active
- endolysosome membrane
- late endosome
- vesicle
- cytosol
- Golgi apparatus