Ift22 Gene Summary [Mouse]

Predicted to enable GTPase activity. Predicted to be involved in intracellular protein transport. Predicted to act upstream of or within intraciliary transport. Located in centrosome and cilium. Part of intraciliary transport particle B. Is expressed in several structures, including adrenal gland; genitourinary system; gut; nervous system; and respiratory system. Orthologous to human IFT22 (intraflagellar transport 22). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Ift22
Official Name
intraflagellar transport 22 [Source:MGI Symbol;Acc:MGI:1914536]
Ensembl ID
ENSMUSG00000007987
Bio databases IDs NCBI: 67286 Ensembl: ENSMUSG00000007987
Aliases intraflagellar transport 22
Synonyms 3110017O03RIK, CFAP9, FAP9, intraflagellar transport 22, RABL5
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ift22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Signal recognition particle receptor beta subunit
  • Ras of Complex, Roc, domain of DAPkinase

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
regulates
  • BBSome

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • ciliary tip
  • cilia
  • basal bodies
  • centrosome

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Ift22 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cilium morphogenesis
  • intracellular protein transport
  • intraflagellar anterograde transport

Cellular Component

Where in the cell the gene product is active
  • centrosome
  • cilium
  • endomembrane system
  • intraflagellar transport particle B

Molecular Function

What the gene product does at the molecular level
  • GTP binding
  • GTPase activity