Traf3ip1 Gene Summary [Mouse]
Predicted to enable microtubule binding activity and signaling receptor binding activity. Involved in morphogenesis of a polarized epithelium; negative regulation of defense response to virus; and regulation of microtubule cytoskeleton organization. Acts upstream of or within several processes, including embryonic organ development; negative regulation of interferon-beta production; and post-anal tail morphogenesis. Located in axoneme; centrosome; and ciliary basal body. Part of intraciliary transport particle B. Is expressed in genitourinary system and nose. Human ortholog(s) of this gene implicated in Senior-Loken syndrome. Orthologous to human TRAF3IP1 (TRAF3 interacting protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Traf3ip1 |
| Official Name | TRAF3 interacting protein 1 [Source:MGI Symbol;Acc:MGI:1921269] |
| Ensembl ID | ENSMUSG00000034292 |
| Bio databases IDs | |
| Aliases | TRAF3 interacting protein 1 |
| Synonyms | 3930402D05Rik, CFAP116, FAP116, IFT54, MIP-T3, SLSN9, TRAF3 interacting protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Traf3ip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Microtubule-binding protein MIP-T3 C-terminal region
- microtubule binding
- Microtubule-binding protein MIP-T3 CH-like domain
- tubulin binding
- coiled-coil domain
- protein binding
- receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Jeune syndrome
- Senior-Loken syndrome 9
- flu
- insomnia
- short-rib thoracic dysplasia type 6
- astigmatism
- psoriasis
role in cell
- binding
- assembly
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- ciliary transition zone
- fibrillar center
- ciliary tip
- cytoskeleton
- cilia
- basal bodies
- centrosome
- microtubules
- axonemes
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Traf3ip1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of type I interferon production
- regulation of microtubule cytoskeleton organization
- intraflagellar transport
- cilium morphogenesis
- kidney development
- negative regulation of protein phosphorylation
- negative regulation of protein complex assembly
- morphogenesis of a polarized epithelium
- intraflagellar anterograde transport
- negative regulation of defense response to virus
Cellular Component
Where in the cell the gene product is active
- centrosome
- cilium basal body
- cilium
- intraflagellar transport particle B
- ciliary transition zone
- axoneme
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule binding