Kif17 Gene Summary [Mouse]
Enables microtubule motor activity. Involved in anterograde dendritic transport of neurotransmitter receptor complex. Acts upstream of or within microtubule-based process; protein-containing complex localization; and vesicle-mediated transport. Located in several cellular components, including cytoskeleton; periciliary membrane compartment; and photoreceptor cell cilium. Part of kinesin complex. Is active in postsynapse. Is expressed in central nervous system; retina; and testis. Orthologous to human KIF17 (kinesin family member 17). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kif17 |
| Official Name | kinesin family member 17 [Source:MGI Symbol;Acc:MGI:1098229] |
| Ensembl ID | ENSMUSG00000028758 |
| Bio databases IDs | |
| Aliases | kinesin family member 17 |
| Synonyms | 5930435E01Rik, AW492270, KIF17B, KIF3X, kinesin family member 17, KLP-2, mKIAA1405, OSM-3, RGD1562511 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kif17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kinesin motor, catalytic domain
- microtubule binding
- Myosin and Kinesin motor domain
- Kinesin motor domain
- protein binding
- motor domain
- microtubule motor protein
- cargo binding domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- polycythemia vera
- myeloproliferative neoplasm
- myeloproliferative disorder
- insulin-dependent diabetes mellitus
- eosinophilic esophagitis
- androgenic alopecia
- productive infection by HIV-1
role in cell
- expression in
- generation
- long term synaptic depression
- polymerization
- polymerization in
- dynamics
- dynamics in
- generation in
- plasticity
- long-term potentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- cilia
- postsynaptic region
- cellular membrane
- Nucleus
- basal bodies
- vesicles
- axonemes
- cytosol
- connecting cilia
- nuclear rim
- photoreceptor outer segments
- photoreceptor inner segments
- plus end of microtubule
- perikaryon
- dendrites
- postsynaptic density
- axon terminals
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kif17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- protein transport
- cell projection organization
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- cilium basal body
- kinesin complex
- neuron projection
- axoneme
- microtubule
- photoreceptor outer segment
- microtubule organizing center
- dendrite cytoplasm
- cilium
- cytosol
- photoreceptor inner segment
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- plus-end-directed microtubule motor activity
- microtubule binding