Mettl15 Gene Summary [Mouse]
Predicted to enable rRNA (cytosine-N4-)-methyltransferase activity. Predicted to be involved in rRNA base methylation. Predicted to be active in mitochondrial matrix. Is expressed in neocortex. Orthologous to several human genes including METTL15 (methyltransferase 15, mitochondrial 12S rRNA N4-cytidine). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mettl15 |
| Official Name | methyltransferase like 15 [Source:MGI Symbol;Acc:MGI:1924144] |
| Ensembl ID | ENSMUSG00000057234 |
| Bio databases IDs | |
| Aliases | methyltransferase like 15 |
| Synonyms | 0610027B03Rik, methyltransferase 15, mitochondrial 12S rRNA N4-cytidine, methyltransferase like 15, METT5D1, RGD1304978 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mettl15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- rRNA (cytosine) methyltransferase
- enzyme
- protein binding
- AdoMet_MTases
- N-methyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mettl15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rRNA base methylation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- rRNA (cytosine-N4-)-methyltransferase activity