Grsf1 Gene Summary [Mouse]
Predicted to enable RNA binding activity. Acts upstream of or within anterior/posterior pattern specification and morphogenesis of embryonic epithelium. Located in mitochondrion. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver; and sensory organ. Orthologous to human GRSF1 (G-rich RNA sequence binding factor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grsf1 |
| Official Name | G-rich RNA sequence binding factor 1 [Source:MGI Symbol;Acc:MGI:106479] |
| Ensembl ID | ENSMUSG00000044221 |
| Bio databases IDs | |
| Aliases | G-rich RNA sequence binding factor 1 |
| Synonyms | D5Wsu31e, G-RICH RNA binding FACTOR, G-rich RNA sequence binding factor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grsf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- mRNA binding
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- atopic dermatitis
role in cell
- expression in
- replication in
- autophagy in
- autophagy
- processing in
- consumption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribonucleoprotein granule
- Mitochondria
- mitochondrial matrix
- mitochondrial nucleoids
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grsf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA processing
- mitochondrial RNA catabolic process
- regulation of RNA splicing
- anterior/posterior pattern specification
- morphogenesis of embryonic epithelium
- mRNA processing
- positive regulation of mitochondrial RNA catabolic process
Cellular Component
Where in the cell the gene product is active
- ribonucleoprotein granule
- cytoplasm
- mitochondrial matrix
- mitochondrion
- nucleoplasm
- mitochondrial nucleoid
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding
- G-quadruplex RNA binding